The association between glucocorticoid receptor gene G1666T polymorphism and cerebral infarction in Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 353-356, 2003.
Article
in Zh
| WPRIM
| ID: wpr-329462
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To ascertain whether the human glucocorticoid receptor (GR) gene polymorphism is associated with cerebral infarction (CI) and essential hypertension (EH) in Chinese.</p><p><b>METHODS</b>This is a case-control study of Chinese DNA samples abstracted from 163 subjects. The samples were analysed by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the intron 4 variant of human GR gene.</p><p><b>RESULTS</b>By analysis of the samples from both sexes as a whole, no association was observed between the EH+CI group and control group, and between the CI group and control group. However, by analysis of the samples from the females, weak association was observed between the EH+CI group and control group, and between the CI group and control group; the frequency of allele G was 0.64 for the EH+CI group, 0.69 for CI group and 0.46 for control group.</p><p><b>CONCLUSION</b>The G allele may be a predisposing gene marker, GR gene intron 4 polymorphism contributes to the development of CI in females.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Restriction Fragment Length
/
Receptors, Glucocorticoid
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Cerebral Infarction
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China
/
Polymerase Chain Reaction
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Asian People
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Ethnology
/
Gene Frequency
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Female
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Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2003
Type:
Article