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Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism
Acta Pharmaceutica Sinica B ; (6): 151-157, 2015.
Article in En | WPRIM | ID: wpr-329680
Responsible library: WPRO
ABSTRACT
The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease (NAFLD), obesity and other metabolic diseases, are of increasing public health concern due to their increasing prevalence in the population. Besides their well-characterized functions in cholesterol homoeostasis and nutrient absorption, bile acids are also important metabolic regulators and function as signaling hormones by activating specific nuclear receptors, G-protein coupled receptors, and multiple signaling pathways. Recent studies identified a new signaling pathway by which conjugated bile acids (CBA) activate the extracellular regulated protein kinases (ERK1/2) and protein kinase B (AKT) signaling pathway via sphingosine-1-phosphate receptor 2 (S1PR2). CBA-induced activation of S1PR2 is a key regulator of sphingosine kinase 2 (SphK2) and hepatic gene expression. This review focuses on recent findings related to the role of bile acids/S1PR2-mediated signaling pathways in regulating hepatic lipid metabolism.
Key words
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: En Journal: Acta Pharmaceutica Sinica B Year: 2015 Type: Article
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: En Journal: Acta Pharmaceutica Sinica B Year: 2015 Type: Article