Chemical constituents of Swertia delavayi and their anti-hepatitis B virus activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 897-902, 2015.
Article
in En
| WPRIM
| ID: wpr-330213
Responsible library:
WPRO
ABSTRACT
Fifteen known compounds were isolated from Swertia delavayi by silica gel, Sephadex LH-20 and Rp-18 column chromatographies. Based on extensive spectroscopic analysis (MS, 1H, 13C-NMR), their structures were identified aserythrocentaurin (1), erythrocentaurindimethylacetal (2), sweroside (3), swertiamarin (4), gentiopicroside (5), swertiakoside A (6), 2'-O-acetylswertiamarin (7), 4'-O-[(Z) -coumaroyl] swertiamarin (8), 1,5,8-trihydroxy-3-methoxyxanthone (9), 8-O-β-D-glucopyranosyl-1-hydroxy-2,3, 5-trimethoxyxanthone (10), 8-O-[β-D-xyl- opyranosyl-(1 --> 6)-β-D-glucopyranosyl]-7,8-dihydroxy-3-methoxyxanthone (11), isovitexin (12), β-sitosterol (13), daucosterol (14), and oleanolic acid (15). Among them, ten ones (14, 7-11, 13) were obtained from S. delavayi for the first time. The isolates were evaluated for their anti-HBV activities in HepG 2. 2. 15 cell line in vitro. The results showed that compound 1, 2, 6, 7, 9 and 12 exhibited significant inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.46 mmol x L(-1).
Full text:
1
Index:
WPRIM
Main subject:
Antiviral Agents
/
Drugs, Chinese Herbal
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Magnetic Resonance Imaging
/
Molecular Structure
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Chemistry
/
Hepatitis B virus
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Spectrometry, Mass, Electrospray Ionization
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Swertia
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Genetics
Language:
En
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article