Correlation of ornidazole concentration in saliva and serum of healthy volunteers / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.</p><p><b>METHODS</b>Six volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.</p><p><b>RESULTS</b>The concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.</p><p><b>CONCLUSION</b>Detection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.</p>