The action of decorin in anti-fibrosis and anti-cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 222-225, 2007.
Article
in Zh
| WPRIM
| ID: wpr-331360
Responsible library:
WPRO
ABSTRACT
Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Proteoglycans
/
Fibrosis
/
Recombinant Proteins
/
Chemistry
/
Extracellular Matrix Proteins
/
Transforming Growth Factor beta1
/
Decorin
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ErbB Receptors
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article