Physiological and pathophysiological meanings of gastrointestinal smooth muscle motor unit SIP syncytium / 生理学报
Acta Physiologica Sinica
; (6): 621-627, 2016.
Article
in Zh
| WPRIM
| ID: wpr-331624
Responsible library:
WPRO
ABSTRACT
Gastrointestinal smooth muscle layer contains two kinds of interstitial cells with special differentiation, i.e., interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor α-positive (PDGFRα) cells. The ICC and PDGFRαcells contact with smooth muscle cells (SMCs) by gap junctions and regulate contractive function of the SMCs. Therefore, these three kinds of cells constitute a functional syncytium, i.e., the SMC, ICC and PDGFRαcells syncytium (SIP syncytium). Various neurotransmitters, humoral factors, endogenous bioactive molecules, as well as drugs regulate gastrointestinal motility through the SIP syncytium. In this review, we introduce the concept of SIP syncytium and summarize functions of the syncytium, as well as its physiological and pathological significances.
Full text:
1
Index:
WPRIM
Main subject:
Giant Cells
/
Receptor, Platelet-Derived Growth Factor alpha
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Myocytes, Smooth Muscle
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Interstitial Cells of Cajal
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Gastrointestinal Motility
/
Muscle, Smooth
Limits:
Humans
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2016
Type:
Article