Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 205-208, 2006.
Article
in Zh
| WPRIM
| ID: wpr-331721
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI).</p><p><b>METHODS</b>Thirty-six patients scheduled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT + PRO group, 9 patients in each group. Changes of superoxide dismutase (SOD), lipid peroxide (LPO), ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), alanine aminotransferase (ALT) activity, and the ultrastructure of liver tissue were dynamically observed.</p><p><b>RESULTS</b>Compared with the control group, SOD activity was significantly higher, LPO concentration, TXB2/6-keto-PGF1alpha ratio and ALT value were significantly lower (P < 0.05 and P < 0.01) in the LGT group, the PRO group and the LGT + PRO group during HIRI, with the abnormal changes of hepatic ultrastructure 25 min after reperfusion significantly alleviated in the three treated group.</p><p><b>CONCLUSION</b>Combination of ligustrazine and propofol shows protective effect on liver by decreasing oxygen free radical level, reducing lipid peroxidation and adjusting TXA2/PGI2 imbalance after hepatic ischemia-reperfusion in patients undergoing hepatic cancer surgery.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pyrazines
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Superoxide Dismutase
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General Surgery
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Blood
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6-Ketoprostaglandin F1 alpha
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Reperfusion Injury
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Propofol
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Therapeutic Uses
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Drug Therapy, Combination
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Lipid Peroxides
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2006
Type:
Article