Elevation of Serum Ferritin is Associated with the Outcome of Patients with Newly Diagnosed Multiple Myeloma
The Korean Journal of Internal Medicine
; : 368-373, 2009.
Article
in En
| WPRIM
| ID: wpr-33198
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Serum ferritin is a marker of acute phase reactions and iron storage. In addition, hematologic malignancies are associated with elevated serum ferritin levels. Other studies have suggested that ferritin is a surrogate for advanced disease and has an impact on relapse, because elevated serum ferritin predicts overall survival (OS) and relapse-free survival following autologous stem cell transplantation for lymphomas.METHODS:
We studied 89 consecutive patients with newly diagnosed multiple myeloma to determine the value of serum ferritin in comparison with known prognostic factors.RESULTS:
The OS in the elevated serum ferritin group (> or =300 ng/mL) was shorter than that in the normal serum ferritin group (<300 ng/mL, p<0.001) after a median follow-up of 25 months. In univariate analysis, elevated ferritin was correlated with poor survival in the patients (relative risk [RR], 2.588; 95% confidence interval [CI], 1.536 to 4.358; p<0.001). Furthermore, multivariate analysis showed that elevated serum ferritin was an independent predictor of mortality in patients with multiple myeloma (RR, 2.594; 95% CI, 1.403 to 4.797; p=0.002).CONCLUSIONS:
The serum ferritin can a prognostic parameter of survival as well as disease activity in patients with multiple myeloma.Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
C-Reactive Protein
/
Proportional Hazards Models
/
Beta 2-Microglobulin
/
Ferritins
/
Multiple Myeloma
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2009
Type:
Article