Relationship between expression of Bax and Bcl-2 proteins and apoptosis in radiation compound wound healing of rats / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 135-138, 2003.
Article
in En
| WPRIM
| ID: wpr-332902
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the expression of Bax, Bcl-2 proteins, and apoptosis in radiation compound wound healing of rats.</p><p><b>METHODS</b>Apoptosis, Bax and Bcl-2 proteins were estimated by in situ terminal labeling (TUNEL) and immunohistochemical methods.</p><p><b>RESULTS</b>(1) Changes of the apoptosis in wound healing showed three typical characteristics: early occurrence, high frequency and delayed disappearance after radiation to rats when compared with those of simple wound group, which might be an important reason for radiation-induced delayed wound healing. (2) The expression of Bax protein increased evidently with the increment of apoptosis and showed a good corresponding relationship with the apoptotic frequency in the process of wound healing. While the expression of Bcl-2 protein decreased obviously as the apoptosis reached a maximum and showed increasing tendency up to normal level when the apoptosis decreased distinctively.</p><p><b>CONCLUSIONS</b>Bax and Bcl-2 proteins play an important role in the apoptotic regulation of radiation compound wound healing in rats.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Radiation Effects
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Skin
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Wound Healing
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Immunohistochemistry
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Proto-Oncogene Proteins
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Rats, Wistar
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Apoptosis
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Proto-Oncogene Proteins c-bcl-2
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Bcl-2-Associated X Protein
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Traumatology
Year:
2003
Type:
Article