Effects of Ginsenoside Rb1 on proliferation of Schwann cells in culture / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 365-368, 2002.
Article
in En
| WPRIM
| ID: wpr-332931
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells in culture.</p><p><b>METHODS</b>Applying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.</p><p><b>RESULTS</b>Ginsenoside Rb(1) (10 microg/ml) significantly induced Schwann cell proliferation, the effect was similar to NGF (50 microg/ml). At high concentrations of Ginsenoside Rb(1) (1 mg/ml), the proliferation of Schwann cells was significantly inhibited.</p><p><b>CONCLUSIONS</b>Ginsenoside Rb(1) at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at higher concentrations the drug is cytotoxic for Schwann cells.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Physiology
/
Rats, Inbred Strains
/
Schwann Cells
/
Sciatic Nerve
/
Immunohistochemistry
/
Cell Division
/
Cells, Cultured
/
Probability
/
Sensitivity and Specificity
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Traumatology
Year:
2002
Type:
Article