Progress in calcium regulation in myocardial and vascular ischemia-reperfusion injury / 生理学报
Acta Physiologica Sinica
;
(6): 321-326, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-333195
ABSTRACT
Ischemia-reperfusion injury (IRI) has been recognized as a serious problem for therapy of cardiovascular diseases. Calcium regulation appears to be an important issue in the study of IRI. This article reviews calcium regulation in myocardial and vascular IRI, including the calcium overload and calcium sensitivity in IRI. This review is focused on the key players in Ca(2+) handling in IRI, including membrane damage resulting in increase in Ca(2+) influx, reverse-mode of Na(+)-Ca(2+) exchangers leading to increased Ca(2+) entry, the decreased activity of sarcoplasmic reticulum (SR) Ca(2+)-ATPase causing SR Ca(2+) uptake dysfunction, and increased activity of Rho kinase. These key players in Ca(2+) homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sarcoplasmic Reticulum
/
Myocardial Reperfusion Injury
/
Calcium
/
Sodium-Calcium Exchanger
/
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/
Heart
/
Homeostasis
/
Metabolism
/
Myocardium
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2012
Type:
Article
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