Hemodynamic effects of aminophylline and nifedipine in patients with high altitude pulmonary edema / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To evaluate the hemodynamic effects of aminophylline and nifedipine in patients with HAPE.</p><p><b>METHODS</b>10 patients with HAPE undergone Swan-Ganz catheter. The parameters of hemodynamics and arterial blood gases in HAPE were measured before and after administration of nifedipine 20 mg sublingually and aminophylline 0.25 g intravenously respectively.</p><p><b>RESULTS</b>After administering 0.25 g aminophylline the mPAP and PVR significantly decreased, the cardiac output and the level of PaO2, SaO2 increased obviously, the mSAP, HR did not change so much. After using 20 mg nifedipine, the mPAP, PVR and mSAP also decreased, while the cardiac output, HR and the level of PaO2, SaO2 did not show any changes.</p><p><b>CONCLUSION</b>Both of aminophylline and nifedipine can attenuate pulmonary hypertension in patients with HAPE, but the effect of aminophylline was better than the effect of nifedipine.</p>