Establishment and evaluation of a modified plasma protamine paracoagulation test / 南方医科大学学报
Journal of Southern Medical University
; (12): 1626-1628, 2011.
Article
in Zh
| WPRIM
| ID: wpr-333846
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a modified plasma protamine paracoagulation test.</p><p><b>METHODS</b>Plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-dimer (D-D) tests were performed for the plasma samples collected from 98 cases of disseminated intravascular coagulation (DIC) and 156 normal subjects. The sensitivity and specificity of the 3 tests were analyzed. The plasma samples from 8 cases of suspected myocardial infarction were detected using modified plasma protamine paracoagulation for diagnostic purpose.</p><p><b>RESULTS</b>The sensitivity of plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-D tests was 16.33%, 88.76% and 77.56%, and the specificity was 100%, 88.46% and 97.44%, respectively. Positive results occurred earlier in modified plasma protamine paracoagulation test than in plasma protamine paracoagulation and D-D tests in 5 cases of myocardial infarction.</p><p><b>CONCLUSION</b>The modified plasma protamine paracoagulation test has a higher sensitivity than plasma protamine paracoagulation test and a higher specificity than D-D test, and can be helpful in early diagnosis of thrombosis and fibrinolysis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Thrombosis
/
Blood
/
Blood Coagulation Tests
/
Protamines
/
Sensitivity and Specificity
/
Diagnosis
/
Methods
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article