Evaluation of cyclodextrin inclusion of the volatile components in compound traditional Chinese medicine / 南方医科大学学报
Journal of Southern Medical University
; (12): 1337-1340, 2006.
Article
in Zh
| WPRIM
| ID: wpr-334928
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the factors affecting cyclodextrin (CD) inclusion of the volatile components in compound traditional Chinese medicines and evaluate the stability of the inclusion compound.</p><p><b>METHODS</b>This study took Gengnian compound as an example to examine the factors affecting the inclusion process according to the inclusion compound utilization ratio. Orthogonal design method was employed optimize the parameters in the inclusion process. The moisture absorption rate of the beta-CD inclusion compound was determined in different humidity and Q10 was used to predict its.</p><p><b>RESULTS</b>The inclusion method, inclusion compound dosage, temperature, inclusion time, and the drying method could all obviously influence the inclusion process. The results of orthogonal design study showed that the optimal beta-CD inclusion of Gengnian compound volatile components could be achieved by adding 8-fold volume of beta-CD and stirring for 3 h at room temperature. Stability experiment showed that the humility did not significantly influence the inclusion compound, which can be stable for 1.26 years.</p><p><b>CONCLUSION</b>This study comprehensively examines the factors affecting the inclusion process and the stability of the inclusion compound, and provides experimental basis for application and study of the inclusion technology.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oils, Volatile
/
Drugs, Chinese Herbal
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Chemistry
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Technology, Pharmaceutical
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Beta-Cyclodextrins
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Drug Combinations
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Drug Stability
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Methods
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article