Therapeutic effect of glucose-6-phosphate polyclonal antibody on vasogenic brain edema in rats / 南方医科大学学报
Journal of Southern Medical University
; (12): 1041-1043, 2006.
Article
in Zh
| WPRIM
| ID: wpr-334997
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the therapeutic effect of glucose-6-phosphate polyclonal antibody (G-6-P pAb) on vasogenic brain edema (VBE) in rats.</p><p><b>METHODS</b>Sixty Wistar rats were randomly divided into normal control group, VBE group, mannitol-treated edema group, and G-6-P pAb-treated edema group. After establishment of rat models of VBE by intraperitoneal injection of phenylephrine in the latter 3 groups, mannitol was injected through the femoral vein in mannitol group and G-6-P pAb injected intraperitoneally in G-6-P pAb group. The permeability of the blood-brain barrier (BBB) was determined by Evans blue (EB) extravasation method, and the brain water content in the gray and white matter measured with a moisture analyzer.</p><p><b>RESULTS</b>G-6-P pAb administration significantly reduced the permeability of BBB as well as the water content in the white matter in comparison with mannitol treatment (P<0.01), but the two treatments showed no obvious difference in reducing the water content in the gray matter (P>0.05).</p><p><b>CONCLUSION</b>Changes in G-6-P activity results in BBB permeability alteration in the condition of VBE, and G-6-P pAb has a selective therapeutic effect against VBE, especially white matter edema.</p>
Full text:
1
Index:
WPRIM
Main subject:
Phenylephrine
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Brain Edema
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Capillary Permeability
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Blood-Brain Barrier
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Random Allocation
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Rats, Wistar
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Glucose-6-Phosphate
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Therapeutic Uses
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Drug Therapy
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Allergy and Immunology
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article