Progress of research on TXNDC5 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 448-450, 2017.
Article
in Zh
| WPRIM
| ID: wpr-335105
Responsible library:
WPRO
ABSTRACT
The protein encoded by TXNDC5 is a member the protein disulfide isomerase family, which has disulfide isomerase activity and can act as the molecular chaperone to reduce the synthesis of abnormal proteins. Its biological functions include anti-oxidation, promoting angiogenesis, taking part in cellular inflammation, and energy metabolism, etc. Studies have demonstrated that the expression of TXNDC5 is increased in many types of tumors including cervical carcinoma, gastric carcinoma and colorectal cancer. Moreover, TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo. This paper aims to summarize the latest progress in research on TXNDC5 in terms of biochemical function, relationship with diseases and the underlying mechanism.
Full text:
1
Index:
WPRIM
Main subject:
Arthritis, Rheumatoid
/
Protein Disulfide-Isomerases
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Diabetes Mellitus
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Genetics
/
Neoplasms
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2017
Type:
Article