Preparation and evaluation of dioscin nanostructured lipid carriers / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3747-3754, 2017.
Article
in Zh
| WPRIM
| ID: wpr-335789
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WPRO
ABSTRACT
In this report, a heat and high-pressure homogenization method was used to prepare dioscin nanostructured lipid carriers, and the formulation of dioscin nanostructured lipid carriers was optimized by central composite design-response surface methodology. In vitro evaluation data showed that the preparation of dioscin nanostructured lipid carriers under optimal process by central composite design-response surface methodology had a spherical shape and homogeneous size distribution, with a particle size of (90.9±0.6) nm, a polydispersity index of (0.253±0.07), Zeta potential of (-45.7±0.5) mV, encapsulation efficiency of (90.2±0.5)%, and the drug loading of (23.30±0.10)%. These results clearly indicate that the preparation of dioscin nanostructured lipid carriers made with the heat and high-pressure homogenization method have very good physical and chemical properties, suitable for therapeutic applications.
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WPRIM
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2017
Type:
Article