Preliminary results of postoperative adjuvant treatment with tamoxifen in colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 143-145, 2007.
Article
in Zh
| WPRIM
| ID: wpr-336486
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate estrogen receptor (ER) expression and the effects of anti-estrogen therapy on the prognosis of colorectal carcinoma.</p><p><b>METHODS</b>ER was measured in fresh colorectal cancer tissues by Dextran-coated charcoal (DCC) assay. The relationships between ER expression and clinicopathological parameters in colorectal cancer were analyzed. Tamoxifen was administrated postoperatively as adjuvant treatment.</p><p><b>RESULTS</b>The positive rate of ER in colorectal tumor tissues was 37.0%. The 5-year survival rates of tamoxifen group and control group were 66.7% and 72.5% respectively, and there was no significant difference between the two groups. The distant metastasis rate of Tamoxifen group was significantly lower than that of control group (3% versus 20%).</p><p><b>CONCLUSION</b>Some colorectal carcinomas are hormone-dependent tumors, and anti-estrogen therapy has no effect on them.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Postoperative Period
/
Prognosis
/
Tamoxifen
/
Colorectal Neoplasms
/
Receptors, Estrogen
/
Survival Rate
/
Treatment Outcome
/
Chemotherapy, Adjuvant
/
Therapeutic Uses
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2007
Type:
Article