Determination of R(-)- isomer in repaglinide tablets by capillary electrophoresis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 145-149, 2014.
Article
in Zh
| WPRIM
| ID: wpr-336728
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.</p><p><b>METHODS</b>An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5).</p><p><b>RESULTS</b>Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.</p><p><b>CONCLUSION</b>The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.</p>
Full text:
1
Index:
WPRIM
Main subject:
Piperidines
/
Stereoisomerism
/
Tablets
/
Carbamates
/
Electrophoresis, Capillary
/
Methods
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2014
Type:
Article