Expression of vascular endothelial growth factor C and its correlation with lymph node metastasis in colorectal carcinoma / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 596-598, 2004.
Article
in En
| WPRIM
| ID: wpr-336967
Responsible library:
WPRO
ABSTRACT
To study the expression of vascular endothelial growth factor C (VEGF-C) in colorectal carcinoma and its relationship with lymph node metastasis, the expression of VEGF-C protein in colorectal carcinoma tissues obtained from 94 patients who underwent radical resection was immunohistochemically detected. Meanwhile, the expression of VEGF-C mRNA in 4 colorectal carcinoma cell lines was examined by reverse transcription polymerase chain reaction (RT-PCR). VEGF-C protein was found to be expressed in 53.2% of patients. The expression was more frequently detected in tumors with lymph node metastasis than in those without metastasis (P<0.01), and there was significant correlation between its expression and lymphatic invasion, TNM stage (P<0.01). However, no significant correlation was found between its expression and the age, gender, tumor location, depth of invasion and vascular invasion. 2 of the 4 colorectal carcinoma cell lines, including LoVo and LoVo-5FU, expressed VEGF-C mRNA. The expression of VEGF-C is closely related to lymph node metastasis, and it might take part in the tumor lymphangiogenesis.
Full text:
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Index:
WPRIM
Main subject:
Pathology
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RNA, Messenger
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Carcinoma, Papillary
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Colorectal Neoplasms
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Adenocarcinoma
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Vascular Endothelial Growth Factor C
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Lymphangiogenesis
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Genetics
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Lymph Nodes
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Lymphatic Metastasis
Limits:
Aged
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Female
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Humans
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Male
Language:
En
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2004
Type:
Article