Role of interleukin-18 in pathogenesis of acute graft-versus-host disease / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 452-454, 2002.
Article
in Zh
| WPRIM
| ID: wpr-337648
Responsible library:
WPRO
ABSTRACT
To investigate the relationship between interleukin-18 (IL-18) and human acute graft-versus-host disease (aGVHD), 26 patients undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT) were included in this study. IL-18 secreted by peripheral blood mononuclear cells (MNCs) was measured by enzyme-linked immunosorbent assay (ELISA) before transplantation and during aGVHD. The results showed that grade I GVHD and grades III-IV GVHD developed in 10 and 5 cases, respectively. The levels in the supernatants of MNCs from patients with aGVHD were significantly higher than those in the cases without aGVHD. The levels of IL-18 were correlated with the severity of aGVHD. It is concluded that IL-18 plays an important role in the development of aGVHD.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Therapeutics
/
Leukemia
/
Acute Disease
/
Interleukin-18
/
Peripheral Blood Stem Cell Transplantation
/
Graft vs Host Disease
/
Hematopoiesis
/
Infections
Type of study:
Etiology_studies
Limits:
Adolescent
/
Adult
/
Child
/
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2002
Type:
Article