Meta-analysis of Dengzhanxixin injection treatment for unstable angina pectoris / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2768-2773, 2012.
Article
in Zh
| WPRIM
| ID: wpr-338021
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy and safety of Dengzhanxixin injection for unstable angina pectoris.</p><p><b>METHOD</b>All clinical studies of Dengzhanxixin injection for unstable angina pectoris (UAP) were searched from Cochrane library, Medline, EM-base, CBM, CNKI, Wanfang and VIP. Quality assessment and information extraction were done by two independent screening . The quality of the included documents was evaluated by the Cochrane Collaboration's tool for assessing risk of bias and allocation concealment. Revman 5.1.4 software was used for data analysis.</p><p><b>RESULT</b>A total of 17 randomized controlled trials were included (1 644 patients), in which, only 2 studies were true RCT, 1 study used single blind method, while other studies did not mention allocation concealment, blind and loss-up information. Meta-analysis showed that the Dengzhanxixin injection group was better than the conventional treatment group in efficiency (OR = 3.54, 95% CI [2.60-4.82]) and ECG (OR = 2.36, 95% CI[1.88-2.96]). Researches with ADR/AE information of Dengzhanxixin injection showed that the symptoms of ADR/AE were slight. This study may exist publication bias.</p><p><b>CONCLUSION</b>Dengzhanxixin injection on the basis of conventional treatment can improve the efficacy of the treatment of unstable angina pectoris. However, due to the sample size of included studies were small and of lower quality, conclusions above still need high-qualitied randomized, double-blind, controlled trials be confirmed.</p>
Full text:
1
Index:
WPRIM
Main subject:
Drugs, Chinese Herbal
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Randomized Controlled Trials as Topic
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Therapeutic Uses
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Drug Therapy
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Angina, Unstable
Type of study:
Clinical_trials
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Systematic_reviews
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article