Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis / 南方医科大学学报
Journal of Southern Medical University
; (12): 156-159, 2009.
Article
in Zh
| WPRIM
| ID: wpr-339040
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.</p><p><b>METHODS</b>The expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.</p><p><b>RESULTS</b>The expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues (P<0.01). A positive correlation was found between survivin and COX-2 expressions and the pathological grade (P<0.01), but their expressions were not correlated to the patients' gender, age or surgical approaches (P>0.05). An obviously lowered recurrence rate was observed in patients with resection of the bone segment compromised by the tumor and subsequent bone grafting. Survivin and COX-2 were not independent risk factors of the prognosis of GCT.</p><p><b>CONCLUSION</b>Survivin and COX-2 expressions may participate in the pathogenesis and development of GCT, but is not indicative of the prognosis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Bone Neoplasms
/
Giant Cell Tumor of Bone
/
Cyclooxygenase 2
/
Inhibitor of Apoptosis Proteins
/
Genetics
/
Metabolism
/
Microtubule-Associated Proteins
Type of study:
Prognostic_studies
Limits:
Adolescent
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Adult
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article