Expression and location of heme oxygenase in the lung of experimental cirrhotic rats / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 599-601, 2003.
Article
in Zh
| WPRIM
| ID: wpr-339155
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To observe the function of heme oxygenase (HO) in the lung damage in hepatic cirrhosis rats.</p><p><b>METHODS</b>Liver cirrhosis model rats were made by CCl4. Lung samples taken from normal and cirrhotic rats were examined for HO-1 and HO-2 protein and expression distribution with immunohistochemical staining and western blot.</p><p><b>RESULTS</b>Liver cirrhosis model rats were successfully constructed. There was a notable increase of HO-1 staining (0.062+/-0.021 vs 0.185+/-0.044, t=11.24, P<0.01) and protein expression (0 vs 5294.92+/-46.02, t=11.45, P<0.01) in both vascular and bronchial smooth muscle cells and endothelium in cirrhotic rats, however, no statistical difference of HO-2 between cirrhotic and normal rats was observed.</p><p><b>CONCLUSION</b>The HO-CO pathway is probably involved in the pathogenesis of lung damage in hepatic cirrhosis rats.</p>
Full text:
1
Index:
WPRIM
Main subject:
Carbon Tetrachloride Poisoning
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Rats, Sprague-Dawley
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Heme Oxygenase-1
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Heme Oxygenase (Decyclizing)
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Liver Cirrhosis, Experimental
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Lung
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Metabolism
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Nitric Oxide
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2003
Type:
Article