Serum Levels of Interleukin-8 and Tumor Necrosis Factor-alpha in Coal Workers' Pneumoconiosis: One-year Follow-up Study
Safety and Health at Work
; : 69-79, 2010.
Article
in En
| WPRIM
| ID: wpr-33917
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP).METHODS:
To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine.RESULTS:
The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-alpha level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-alpha (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-alpha were 11.63 pg/mL (sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively.CONCLUSION:
The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-alpha are associated with the progression of CWP.Key words
Full text:
1
Index:
WPRIM
Main subject:
Pneumoconiosis
/
Thorax
/
Fibrosis
/
Biomarkers
/
Inhalation
/
ROC Curve
/
Follow-Up Studies
/
Cytokines
/
Interleukin-8
/
Sensitivity and Specificity
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Language:
En
Journal:
Safety and Health at Work
Year:
2010
Type:
Article