Relationship between aberrant FHIT transcripts and hepatocellular carcinoma / 中华肝脏病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).</p><p><b>METHODS</b>Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.</p><p><b>RESULTS</b>Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.</p><p><b>CONCLUSION</b>FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.</p>