Short-term results of audiological change of nasopharyngeal carcinoma patient after radiotherapy and chemotherapy / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
; (12): 906-909, 2008.
Article
in Zh
| WPRIM
| ID: wpr-339280
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate short-stage results of audiological change of nasopharyngeal carcinoma patients after radiotherapy and chemotherapy treatment.</p><p><b>METHODS</b>According to treatment modus of nasopharyngeal carcinoma, 64 cases (128 ears) patients were divided to simple radiotherapy group (45 cases, 90 ears) and radiotherapy with chemotherapy group (combination treatment group, 19 cases, 38 ears). Meanwhile, 25 cases (50 ears) people took as control group, who had no obviously ear and nose disease. About two or three months after radiotherapy and chemotherapy treatment completion, three groups were detected by otoscopy, pure tone test, tympanogram and eustachian tube function, respectively. Then, hearing variation of all patients after radiotherapy and chemotherapy treatment were investigated and compared each other. At the same time, the character and level of audiological change were also analyzed.</p><p><b>RESULTS</b>Eardrum character of nasopharyngeal carcinoma patients appeared change after radiotherapy. Simple radiotherapy and combination treatment groups were found having hearing impairment and eustachian tube functional disturbance. Moreover, most patients of simple radiotherapy group showed conductive deaf (24%, 22/90), and combination treatment group exhibited mingle (24%, 9/38) or sensorineural deafness (29%, 11/38).</p><p><b>CONCLUSIONS</b>Recent hearing of nasopharyngeal carcinoma patients were damaged by radiotherapy and chemotherapy treatment, radiotherapy treatment induced middle ear or eustachian tube function disturbance, chemotherapy treatment had cochleotoxicity, compared with other treatment, combination treatment was more aggravated hearing impairment.</p>
Full text:
1
Index:
WPRIM
Main subject:
Otitis Media
/
Audiometry, Pure-Tone
/
Therapeutics
/
Antineoplastic Combined Chemotherapy Protocols
/
Case-Control Studies
/
Nasopharyngeal Neoplasms
/
Radiation Oncology
/
Eustachian Tube
/
Hearing Loss
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article