Role of serotonergic neurons in dorsal raphe nuclei in regulation of sleep / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep.</p><p><b>METHODS</b>Stereotaxic, microinjection and polysomnography (PSG) were used in the experiment.</p><p><b>RESULTS</b>Microinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced.</p><p><b>CONCLUSION</b>Serotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased</p>