Research progress on ebola virus glycoprotein / 病毒学报
Chinese Journal of Virology
; (6): 233-237, 2013.
Article
in Zh
| WPRIM
| ID: wpr-339947
Responsible library:
WPRO
ABSTRACT
Ebola virus (EBOV) causes outbreaks of a highly lethal hemorrhagic fever in humans and there are no effective therapeutic or prophylactic treatments available. The glycoprotein (GP) of EBOV is a transmembrane envelope protein known to play multiple functions including virus attachment and entry, cell rounding and cytotoxicity, down-regulation of host surface proteins, and enhancement of virus assembly and budding. GP is the primary target of protective immunity and the key target for developing neutralizing antibodies. In this paper, the research progress on genetic structure, pathogenesis and immunogenicity of EBOV GP in the last 5 years is reviewed.
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Virology
/
Glycoproteins
/
Viral Envelope Proteins
/
Virus Assembly
/
Hemorrhagic Fever, Ebola
/
Ebolavirus
/
Allergy and Immunology
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Chinese Journal of Virology
Year:
2013
Type:
Article