Study on the relationship between glutathione S transferase mu gene deletion and leukemia in workers exposed to benzene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 38-41, 2002.
Article
in Zh
| WPRIM
| ID: wpr-340122
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between glutathione S transferase M1(GST mu) gene deletion and leukemia in workers exposed to benzene.</p><p><b>METHODS</b>A matched population-based case-control survey with multivariate Logistic regression analysis was conducted in this study.</p><p><b>RESULTS</b>In the population of 34 patients and their matched controls, the absence of the GST mu genotype conferred odds ratio of 3.6. It suggested that GST mu was an important determinant of heterogeneity in individual susceptibility to leukemia associated with exposure to benzene. The single-variance analysis indicated that these markedly significant factors were GST mu gene deletion, GST mu isoenzyme activity, duration of exposure, GST isoenzyme activity, smoking quantity and average concentration of benzene in workshop air. The multivariate analysis indicated that these markedly significant factors were GST mu gene deletion, duration of exposure to benzene and GST mu isoenzyme activity.</p><p><b>CONCLUSION</b>GST mu gene deletion may be associated with increased risk of leukemia in workers exposed to benzene and is one of genetically determined factors.</p>
Full text:
1
Index:
WPRIM
Main subject:
Benzene
/
Leukemia
/
Case-Control Studies
/
Logistic Models
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Multivariate Analysis
/
Occupational Exposure
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Gene Deletion
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Toxicity
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Genetics
/
Glutathione Transferase
Type of study:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2002
Type:
Article