An epidemiological study on human rhinovirus C in hospitalized children with respiratory tract infections / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1094-1099, 2016.
Article
in Zh
| WPRIM
| ID: wpr-340560
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the detection rates, epidemical characteristics, and clinical features of human rhinovirus C (HRV-C) in hospitalized children with respiratory tract infections (RTIs) in Suzhou, China.</p><p><b>METHODS</b>A total of 1 702 hospitalized children with RTIs from January to December, 2014 were enrolled, and 1 702 nasopharyngeal aspirate samples were collected from all children. RT-PCR was used to measure HRV mRNA, and quantitative real-time PCR combined with high-resolution melting curve was used to measure HRV-C.</p><p><b>RESULTS</b>Of all children, 244 (14.34%) were detected to have HRV infection, among whom 69 (69/244, 28.3%) had HRV-C infection. The rate of mixed infection of HRV-C with other viruses and bacteria was 61% (42/69). HRV-C was detected in each month of the year, and the detection rate of HRV-C in autumn was significantly higher than that in spring, summer, and winter (P<0.05). The children aged 2-5 years had a significantly higher detection rate of HRV-C than those in the other age groups (P<0.05). Compared with HRV-A/B infection, HRV-C infection led to significantly higher proportions of patients with lobar pneumonia and acute exacerbation of asthma (P<0.05), as well as patients with increased neutrophil count and CRP level (P<0.05). There were no significant differences in sex distribution or other clinical manifestations (P>0.05).</p><p><b>CONCLUSIONS</b>HRV-C infection accounts for about 1/3 of HRV infection, with a high incidence rate in autumn. The rate of mixed infection of HRV-C with other viruses and bacteria is high, and children aged 2-5 years have the highest detection rate of HRV-C. Children with HRV-C infection have similar clinical manifestations as those with HRV-A/B infection.</p>
Full text:
1
Index:
WPRIM
Main subject:
Respiratory Tract Infections
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Rhinovirus
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Seasons
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Virology
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Child, Hospitalized
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Classification
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Real-Time Polymerase Chain Reaction
Limits:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article