Spectrum-effect relationship of Moutan cortex against lipopolysaccharide-induced acute lung injury / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4389-4393, 2014.
Article
in Zh
| WPRIM
| ID: wpr-341848
Responsible library:
WPRO
ABSTRACT
This research is to study the relationship between HPLC fingerprints of Moutan Cortex, Paeoniae Radix Rubra and Paeoniae Radix Alba and their activity on lipopolysaccharide-induced acute lung injury. HPLC fingerprints of each extract of Moutan Cortex,Paeoniae Radix Rubra and Paeoniae Radix Alba were established by an optimized HPLC-MS method. The activities of all samples against protein and tumor necrosis a factor were tested by the model of lipopolysaccharide-induced acute lung injury. The possible relationship between HPLC-MS fingerprints and the activitieswere deduced by the Partial least squares regression analysis method. Samples were analyzed by HPLC-MS/MS to identify the major peaks. The results showed that each sample had some effect on acute lung injury. Four components with a lager contribution rate of efficacy were calculated by the research of spectrum-effect relationship. Moutan Cortex exhibited good activity on acute lung injury, and gallic acid, paeoniflorin, galloylpaeoniflorin and paeonol were the main effective components.
Full text:
1
Index:
WPRIM
Main subject:
Acetophenones
/
Pharmacology
/
Drugs, Chinese Herbal
/
Chemistry
/
Lipopolysaccharides
/
Chromatography, High Pressure Liquid
/
Rats, Wistar
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Plant Roots
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Bridged Bicyclo Compounds, Heterocyclic
/
Paeonia
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article