Screening and expression of tumor markers in colorectal carcinoma / 中华外科杂志
Chinese Journal of Surgery
; (12): 459-461, 2007.
Article
in Zh
| WPRIM
| ID: wpr-342145
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To screen the tumor markers of colorectal carcinoma and to investigate their expression in preoperative and postoperative serum.</p><p><b>METHODS</b>The distinct proteins in serum were detected in 87 cases of colorectal carcinoma, 68 cases of benign colorectal diseases and 56 healthy people by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). The distinct proteins in serum were detected in 87 cases of colorectal carcinoma pre-operation and within 15 days post operation with the same methods.</p><p><b>RESULTS</b>Two proteins with mass-to-charge ratios of 5955 Da and 5972 Da were screened. Compared with benign colorectal diseases and healthy control, the expression of the two proteins was obviously up-regulated in colorectal carcinoma (P < 0.01). Compared with pre-operation, the expression on the 1(st) day post operation was obviously up-regulated (P < 0.01), and the expression decreased to pre-operative level on the 4(th) day post operation. The expression of the two proteins turned out to be a descendent tendency form the 4(th) to 15(th) day post operation, but did not reach the normal level as found in healthy control.</p><p><b>CONCLUSIONS</b>Two proteins with mass-to-charge ratios of 5955 Da and 5972 Da could be regarded as tumor markers in colorectal carcinoma, the expression may has some regularity.</p>
Full text:
1
Index:
WPRIM
Main subject:
Postoperative Period
/
General Surgery
/
Blood
/
Preoperative Care
/
Colorectal Neoplasms
/
Biomarkers, Tumor
/
Mass Screening
/
Reproducibility of Results
/
Sensitivity and Specificity
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article