Rotavirus surveillance data from Kunming Children's Hospital, 1998 - 2001 / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 396-399, 2004.
Article
in Zh
| WPRIM
| ID: wpr-342300
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the epidemiological status on rotavirus diarrhea in Kunming to improve the rotavirus vaccine immunization program.</p><p><b>METHODS</b>A hospital-based sentinel surveillance program for rotavirus was set up among children less than 5 years old with acute diarrhea in Kunming Children's Hospital. Clinical information and fecal specimens were collected and rotavirus were detected by polyacrylamide gel electrophoresis (PAGE) and/or enzyme linked immunosorbent assay (ELISA). Positive specimens were further serotyped or genotyped by ELISA and/or RT-PCR.</p><p><b>RESULTS</b>During the three years of surveillance, 466 specimens were collected. Rotavirus were detected on 246 (52.8%) specimens. 97% of the rotavirus diarrhea cases occurred among children less than 2 years old. There was a peak of admissions for rotavirus diarrhea cases between October and December which accounted for 48% of all the rotavirus hospitalizations each year. Among 204 specimens with G serotyping, the predominant strain was serotype G1 (47.5%) followed by G2 (17.6%), G3 (15.7%), G9 (4.9%) and G4 (1.0%). Mixed infection (2.5%) were rare and 22 specimens (10.8%) remained non-typeable. P genotyping showed P[4], P[8] and P[6] were the most common strains, accounting for 29.3%, 27.6% and 13.8% respectively. P[4]G2 was the most common strain which accounted for 34.1% (14/41) followed by P[8]G1 (29.3%) and P[6]G9 (12.2%). Another 7 uncommon P-G combinations were also identified.</p><p><b>CONCLUSION</b>Rotavirus was the major cause of acute diarrhea in Kunming. An effective rotavirus vaccine for prevention and control of rotavirus diarrhea should be developed.</p>
Full text:
1
Index:
WPRIM
Main subject:
Rotavirus Infections
/
Virology
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Enzyme-Linked Immunosorbent Assay
/
Serotyping
/
China
/
Epidemiology
/
Classification
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Rotavirus
/
Sentinel Surveillance
/
Reverse Transcriptase Polymerase Chain Reaction
Type of study:
Screening_studies
Limits:
Child, preschool
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Female
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Humans
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Infant
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article