Distribution of hepatitis B virus genotype in 5 cities of Fujian province and the clinical implications of HBV genotype / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 251-255, 2004.
Article
in Zh
| WPRIM
| ID: wpr-342342
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the prevalence of hepatitis B virus (HBV) genotype in 5 cities of Fujian province and the clinical implications of distinct genotypes in HBV-related liver diseases.</p><p><b>METHODS</b>HBV genotype was determined by the restriction fragment length polymorphism analysis in patients with chronic HBV infection in 5 cities of Fujian province. The relationship between HBV genotype and its clinical implications was studied by multinomal logistic regression and correspondence analysis.</p><p><b>RESULTS</b>Of the 431 HBV DNA positive patients detected by PCR, 275 (63.8%) belonged to HBV genotype B, 100 (23.2%) to genotype C, 51 (11.8%) to genotype D and D-mixed genotype. Genotype A, E and F were not found. Multinomal logistic regression showed that genotype B was more prevalent in Quanzhou and Sanming cities than in Fuzhou (P = 0.002, P = 0.006), and genotype B appeared significantly more common in asymptomatic carriers (ASC), chronic hepatitis B (CHB) and severe hepatitis (SH). Genotype C was most prevalent in patients with liver cirrhosis (LC) (47.0%) than in those with ASC (14.5%) and SH (14.7%) (P = 0.009, P < 0.001). The positive rate of hepatitis B e antigen was higher in patients with genotype C than in those with genotype B and genotype D (56.0% vs. 52.4%, P = 0.008, and 56.0% vs. 30.8%, P = 0.051, respectively). By correspondence analysis, genotype D and D-mixed genotype seemed to be correlated with hepatocellular carcinoma (HCC).</p><p><b>CONCLUSIONS</b>(1) The major popular genotypes of HBV were B, C and D in Fujian. (2) Data of our study suggested that the geographic distribution of genotype B and C might be different in some cities of Fujian. (3) Genotype B might have a tendency to lead to SH in younger patients with chronic hepatitis B and the development of LC might be associated with genotype C among the elder patients. (4) Genotype D appeared to associate with development of HCC, which called for further study to confirm.</p>
Full text:
1
Index:
WPRIM
Main subject:
Virology
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Polymorphism, Restriction Fragment Length
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Logistic Models
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China
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Hepatitis B virus
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Polymerase Chain Reaction
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Multivariate Analysis
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Gene Frequency
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Genetics
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Genotype
Type of study:
Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2004
Type:
Article