Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 1343-1347, 2009.
Article
in Zh
| WPRIM
| ID: wpr-344074
Responsible library:
WPRO
ABSTRACT
Host cell protein phosphatase-1 (PP1) is an important regulator of human immunodeficiency virus-1 (HIV-1) transcription. PP1 is involved in the regulation of HIV-1 transcription, and dephosphorylates RNA polymerase II C-terminal domain (RNAPII CTD) or CycT1-dependent kinase 9 (CDK9) to increase Tat-dependent HIV-1 transcription. In this review, we discuss the action of PP1 in Tat-induced HIV-1 transcription and related to PP1 inhibitors.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Physiology
/
Pyrans
/
Spiro Compounds
/
Transcription, Genetic
/
Chemistry
/
HIV-1
/
Okadaic Acid
/
Anti-HIV Agents
/
Enzyme Inhibitors
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article