In vitro biomineralization of self-assembly oligopeptide T2 / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 798-801, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-346067
ABSTRACT
Oligopeptide T2, a kind of PA (Peptide Amphiphile) molecule, which could build up nano-fiber by self-assembly was designed and synthesized in this study. And the double-diffusion gel system was applied on this molecule to investigate its biomineralization features in vitro. The results showed that T2 could obviously reduce the hydroxyapatite (HA) formation period. And HA was found to possess the characteristics of non-crystalline by analysis of X-ray diffraction (XRD) and scanning electronic microscopy (SEM). These findings point to the conclusion that the negatively charged zone in T2 might make this molecule have the function of promoting HA biomineralization in vitro. And the mechanism responsible for the procession of HA biomineralization needs further research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligopeptides
/
Biocompatible Materials
/
Calcification, Physiologic
/
Chemistry
/
Durapatite
/
Bone Substitutes
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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