Studies on metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3743-3747, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-346846
ABSTRACT
<p><b>OBJECTIVE</b>To study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.</p><p><b>METHOD</b>Total terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS.</p><p><b>RESULT</b>Eight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon.</p><p><b>CONCLUSION</b>Total terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Terpenes
/
Bacteria
/
Chromatography, High Pressure Liquid
/
Swertia
/
Xanthones
/
Alkaloids
/
Anaerobiosis
/
Intestines
/
Ketones
Type of study:
Qualitative research
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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