Antitussive activity comparison of three kinds of Stemonae Radix in Chinese Pharmacopoeia / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3096-3104, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-346963
ABSTRACT
<p><b>OBJECTIVE</b>To compare the antitussive activity of three kinds of Stemonae Radix specified in the Chinese Pharmacopoeia, including roots of Stemona sessilifolia, S. japonica and S. tuberosa.</p><p><b>METHOD</b>The antitussive activity was determined in mouse after cough induction by ammonia aerosol stimulation and the number of cough in 2 min were detected with codeine as positive control.</p><p><b>RESULT</b>All the decoctions, the total alkaloid fractions and non-alkaloid fractions of S. sessilifolia, S. japonica and three chemical types of S. tuberosa showed significant antitussive effect and exhibited a dose-dependent inhibition of coughing. The ED50 values showed that the antitussive activity strength for both total alkaloid fractions and the decoctions are S. tuberosa (Type I) > S. sessilifolia > S. japonica. The total alkaloid fractions had more potent atitussive activity than the decoctions and non-alkaloid fractions. The antitussive activity strength for the three chemical types of S. tuberosa is Type I > Type III > Type II. The samples from different producing areas for the same species of Stemonae Radix had no significant differences in antitussive activity. The result also showed that the honey-processed slice had much stronger antitussive activity than raw slice.</p><p><b>CONCLUSION</b>The antitussive efficacies of Stemonae Radix were influenced by chemical diversity both in same species and among different species, different fractions and processed method.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antitussive Agents
/
Drugs, Chinese Herbal
/
Chemistry
/
Cough
/
Stemonaceae
/
Disease Models, Animal
/
Drug Therapy
/
Mice, Inbred ICR
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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