Expression of IL-8, SP-A and TGF-beta1 in bronchoalveolar lavage fluid of neonates with bronchopulmonary dysplasia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 444-446, 2010.
Article
in Zh
| WPRIM
| ID: wpr-347575
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of interleukin 8 (IL-8), surfactant protein-A (SP-A) and transforming growth factor beta1 (TGF-beta1) in bronchoalveolar lavage fluid (BALF) of neonates with bronchopulmonary dysplasia (BPD).</p><p><b>METHODS</b>Thirty neonates with BPD and 30 gestational age-, gender-, and birth weight-matched neonates without BPD (control group) were enrolled from December 2007 to October 2009. Non-brochoscopic bronchoalveolar lavage was performed. The levels of IL-8, SP-A and TGF-beta1 in BALF were measured using ELISA.</p><p><b>RESULTS</b>The levels of TGF beta1 (47+/-15 microg/mL vs 34+/-13 microg/mL) and IL-8 (54+/-16 microg/mL vs 28+/-13 microg/mL) in the BPD group were significantly higher than those in the control group (P<0.01). In contrast, the contents of SP-A in the BPD group were significantly lower than those in the control group (35+/-16 microg/mL vs 42+/-14 microg/mL;P<0.05).</p><p><b>CONCLUSIONS</b>The increased expression of TGF-beta1 and IL-8 in BALF may be involved in abnormal lung development and maturation in neonates with BPD. The low expression of SP-A in the BPD group suggests that the exogenous SP-A administration may be an option for the treatment of BPD.</p>
Full text:
1
Index:
WPRIM
Main subject:
Physiology
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Bronchopulmonary Dysplasia
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Enzyme-Linked Immunosorbent Assay
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Bronchoalveolar Lavage Fluid
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Chemistry
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Interleukin-8
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Pulmonary Surfactant-Associated Protein A
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Transforming Growth Factor beta1
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Metabolism
Limits:
Female
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Humans
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Male
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Newborn
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Type:
Article