The Effect of Mitomycin on the Experimental Filtering Surgery
Journal of the Korean Ophthalmological Society
; : 530-539, 1993.
Article
in Ko
| WPRIM
| ID: wpr-34769
Responsible library:
WPRO
ABSTRACT
In tiis study, an expenmental model of glaucoma filtering surgery in rabblts was used to evaluate the effect of single intraoperative application of Mitomycin Full-thickness filtering surgery, posterior lip sclerectomy, was performed after application of 0.5mg/ml Mitomycin-soaked Week-Cel(TM) sponge for 5 minutes in one eye of 15 pigmented rabbits and was irrigated copiously with balanced salt solution(BSS(TM)). The same procedure was done in the contralateral eye as a control, using BSS(TM). In Mitomycin-treated group, the filtering blebs were more prominent with sparse vascular tissues and were maintained through postoperative 8 weeks or more. Histologically, there loas was amount of inflammatory reactions in Mitomycin-treated group. The fibroblastic activity and proliferations of the collagen were also suppessed markedly in Mitomycin-treated group. These results suggest that a single intraoperative application of Mitomycin can be used adjunctively to improve the success rate of glaucoma filtering surgery.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Porifera
/
Glaucoma
/
Blister
/
Collagen
/
Mitomycin
/
Filtering Surgery
/
Fibroblasts
/
Lip
/
Loa
Limits:
Animals
Language:
Ko
Journal:
Journal of the Korean Ophthalmological Society
Year:
1993
Type:
Article