Inflammatory myofibroblastic tumor of bladder: a clinicopathologic study of five cases / 中华病理学杂志
Zhonghua Bing Li Xue Za Zhi
; (12): 605-608, 2007.
Article
in Zh
| WPRIM
| ID: wpr-347719
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features, diagnosis and differential diagnosis of inflammatory myofibroblastic tumor of the urinary bladder.</p><p><b>METHODS</b>Excisional specimens from 5 cases of vesical inflammatory myofibroblastic tumor were studied by light microscopy and immunohistochemistry (EnVision). The clinical data were also analyzed.</p><p><b>RESULTS</b>Among the 5 patients studied, 3 were males and 2 were females. The age of the patients ranged from 10 to 53 years (mean age = 35 years). The most common clinical presentation was micturition pain and hematuria. Three cases were located at the dome of the urinary bladder and the remaining 2 cases were found in the left lateral wall. Histologically, the tumor varied from myxoid to highly cellular. The tumor cells were spindle to stellate in shape, widely separated or showed a compact fascicular pattern. There were often associated with mixed inflammatory infiltrates and an irregular meshwork of small dilated vessels. Immunohistochemical study showed that the tumor cells expressed AE1/AE3 (5/5), vimentin (5/5), smooth muscle actin (5/5), calponin (5/5), caldesmon (3/5), desmin (4/5) and anaplastic lymphoma kinase protein (4/5). Follow-up data were available in 4 patients and none had local recurrence or died of this disease.</p><p><b>CONCLUSION</b>Inflammatory myofibroblastic tumour of urinary bladder is a rarely encountered but distinctive neoplasm with intermediate malignant potential.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Rhabdomyosarcoma
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General Surgery
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Vimentin
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Urinary Bladder Neoplasms
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Protein-Tyrosine Kinases
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Calcium-Binding Proteins
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Anion Exchange Protein 1, Erythrocyte
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Cystectomy
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Survival Rate
Type of study:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Zhonghua Bing Li Xue Za Zhi
Year:
2007
Type:
Article