Osteoblasts derived from mesenchymal stem cells harbor immunoregulatory effect / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 50-53, 2005.
Article
in Zh
| WPRIM
| ID: wpr-347828
Responsible library:
WPRO
ABSTRACT
In an attempt to study the immunoregulatory effect of osteoblasts derived from mesenchymal stem cells (MSC), MSC was induced to differentiate into osteoblasts for one week. The growth pattern and the phenotype were evaluated by MTT and flow cytometry respectively. The immunoregulatory effect was tested by the inhibitory effect on T cell proliferation. The result showed that during the differentiation cells grew fast and there was no significant change in the phenotypes but keeping CD73, CD105, CD44, CD29 positive and CD34, CD45, HLA-DR, CD86 negative. Osteocyte derived from MSC also showed immunosuppressive effect on T cell proliferation in adose-dependent manner. It is concluded that osteoblasts derived from MSC also harbored immunoregulatory effect.
Full text:
1
Index:
WPRIM
Main subject:
Osteoblasts
/
Bone Marrow Cells
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T-Lymphocytes
/
Cell Differentiation
/
Cells, Cultured
/
Cell Lineage
/
Cell Biology
/
Cell Proliferation
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Allergy and Immunology
/
Mesenchymal Stem Cells
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2005
Type:
Article