Expression and clinical significance of HMGB1 and RAGE in cervical squamous cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 292-295, 2008.
Article
in Zh
| WPRIM
| ID: wpr-348110
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between high mobility group box1 (HMGB1) and cervical squamous cell carcinoma (CSCC), and explore the role of HMGB1/RAGE pathway in the metastasis of CSCC.</p><p><b>METHODS</b>Levels of HMGB1 mRNA and RAGE mRNA in CSCC and normal cervical tissues were detected by real time quantitative polymerase chain reaction (qRT-PCR), and the level of HMGB1 protein was determined by immunohistochemistry and Western blotting.</p><p><b>RESULTS</b>The mRNA and protein expression of HMGB1 was significantly higher in CSCC than that in normal cervical tissue (P < 0.05), correlated with stage, invasion and metastasis (P < 0.05), but not with tumor size and differentiation (P > 0.05). The levels of RAGE mRNA and HMGB1 mRNA were both significantly higher (r = 0.663, P < 0.05) in metastatic CSCC in comparison with those in the non-metastatic cases.</p><p><b>CONCLUSION</b>HMGB1 is involved in the invasion and metastasis of CSCC, and HMGB1/RAGE pathway plays an important role in the metastasis of CSCC.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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RNA, Messenger
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Immunohistochemistry
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Carcinoma in Situ
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Carcinoma, Squamous Cell
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Receptors, Immunologic
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Signal Transduction
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Gene Expression Regulation, Neoplastic
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Uterine Cervical Neoplasms
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Cervix Uteri
Limits:
Female
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Humans
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2008
Type:
Article