Association between rs780094 polymorphism in GCKR and plasma lipid levels in children and adolescents / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 626-629, 2014.
Article
in Zh
| WPRIM
| ID: wpr-348606
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between rs780094 polymorphism in glucokinase regulatory protein (GCKR) and plasma lipid levels in children and adolescents.</p><p><b>METHODS</b>1 026 Chinese children aged 7 to 18 years were recruited, with anthropometric measurements, detection of plasma lipid levels and genotyping of rs780094 performed. Relationships between polymorphism and plasma lipid levels were tested, using multivariate linear regression and logistic regression.</p><p><b>RESULTS</b>A-allele of rs780094 in GCKR was associated with increased TC, TG and LDL-C levels (b = 0.06 mmol/L, P = 0.037; b = 0.09 mmol/L, P < 0.001; b = 0.05 mmol/L, P = 0.040) under the additive model adjusted for age, age square and gender. The rs780094 in GCKR was also associated with abnormal levels of TG and LDL-C(OR = 1.60, 95% CI1.30-1.97, P < 0.001;OR = 1.35, 95%CI1.02-1.80, P = 0.036).</p><p><b>CONCLUSION</b>The rs780094 in GCKR was associated with plasma lipid levels in children and adolescents while A-allele of rs780094 might serve as genetic factor for the increased plasma lipid levels.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Blood
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Carrier Proteins
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Logistic Models
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Genetics
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Genotype
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Lipids
Type of study:
Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2014
Type:
Article