A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 389-392, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-348860
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.</p><p><b>METHODS</b>Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.</p><p><b>RESULTS</b>A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).</p><p><b>CONCLUSION</b>The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tuberculosis, Pulmonary
/
Polymorphism, Restriction Fragment Length
/
Case-Control Studies
/
Logistic Models
/
Polymerase Chain Reaction
/
Receptors, Calcitriol
/
Genetic Predisposition to Disease
/
Genetics
/
Genotype
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2003
Type:
Article
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