Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation / 药学学报
Yao Xue Xue Bao
; (12): 305-310, 2011.
Article
in Zh
| WPRIM
| ID: wpr-348960
Responsible library:
WPRO
ABSTRACT
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Platelet Aggregation Inhibitors
/
Random Allocation
/
Chemistry
/
Platelet Aggregation
/
Coumaric Acids
Limits:
Animals
Language:
Zh
Journal:
Yao Xue Xue Bao
Year:
2011
Type:
Article