Targeted therapy: resistance and re-sensitization / 癌症
Chinese Journal of Cancer
; (12): 496-501, 2015.
Article
in En
| WPRIM
| ID: wpr-349566
Responsible library:
WPRO
ABSTRACT
The last two decades have witnessed a paradigm shift from cytotoxic drugs to targeted therapy in medical oncology and pharmaceutical innovation. Inspired by breakthroughs in molecular and cellular biology, a number of novel synthesized chemical compounds and recombinant antibodies have been developed to selectively target oncogenic signaling pathways in a broad array of tumor types. Although targeted therapeutic agents show impressive clinical efficacy and minimized adverse effects compared with traditional treatments, the challenging drug-resistant issue has also emerged to limit their benefits to cancer patients. In this regard, we aim to improve targeted therapy by presenting a systematic framework regarding the drug resistance mechanisms and alternative approaches to re-sensitize cancer cells/tissues therapeutically.
Full text:
1
Index:
WPRIM
Main subject:
Signal Transduction
/
Drug Resistance, Neoplasm
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Cancer
Year:
2015
Type:
Article