Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins / 癌症
Chinese Journal of Cancer
;
(12): 325-334, 2015.
Article
in English
| WPRIM
| ID: wpr-349588
ABSTRACT
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways mitochondrial, death receptor, and endoplasmic reticulum pathways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plant Proteins
/
Ribosomes
/
Apoptosis
/
Endoplasmic Reticulum
/
Receptors, Death Domain
/
Ribosome Inactivating Proteins
/
Mitochondria
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2015
Type:
Article
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