Clinicopathologic significance of chromosome 17 polysomy in breast cancer / 中华病理学杂志
Chinese Journal of Pathology
; (12): 88-91, 2008.
Article
in Zh
| WPRIM
| ID: wpr-349967
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathological significance of chromosome 17 polysomy in breast cancer.</p><p><b>METHODS</b>Retrospective study of 200 cases of breast cancer including 106 cases of invasive ductal carcinoma and 94 cases of in-situ carcinoma was performed by fluorescence in-situ hybridization (FISH) to explore the relationship between chromosome 17 polysomy and age, nuclear atypia, lymphatic metastasis, HER2 gene amplification and HER2 protein expression.</p><p><b>RESULTS</b>Twenty-six percent (52/200) of chromosome 17 polysomy was detected in 200 cases of breast ductal carcinoma, all of which were invasive ductal carcinoma. Overall 52. 8% (52/180) of invasive ductal carcinoma cases showed chromosome 17 polysomy, which was correlated to HER2 gene amplification (P = 0.000) and HER-2 protein expression (P=0.000), and to HER2 expression combined with HER2 gene amplification (P=0.001). Chromosome 17 polysomy with or without HER2 gene amplification was also associated with high-grade nuclear atypia (P = 0.012 or P = 0.010) and lymphatic metastasis (P = 0.002 or P = 0.009 ). However, chromosome 17 polysomy with or without HER2 gene amplification was not correlative with the age of patients (P = 1. 000 or P = 0. 415).</p><p><b>CONCLUSION</b>Chromosome 17 polysomy may be related to the nuclear atypia, metastasis, HER2 gene amplification of invasive ductal carcinoma and thus a worse prognosis of the patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Chromosomes, Human, Pair 17
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Breast Neoplasms
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Gene Expression Regulation, Neoplastic
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Gene Amplification
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Chromosome Aberrations
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Genes, erbB-2
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Gene Dosage
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Carcinoma, Ductal
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Genetics
Type of study:
Observational_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2008
Type:
Article